The 1-Cys peroxiredoxin, PRDX-6, suppresses a pro-survival response, including the Flavin monoxygenase, FMO-2, that protects against fungal and bacterial infection
Emma L Button, Jake B. Lewis, Emilia Dwyer, Elise McDonald, Eloise Butler, Fiona Pearson, Elizabeth A. Veal
This paper shows that loss of PRDX-6 in C. elegans increases stress resistance, innate immunity, and longevity by upregulating FMO-2, which protects against fungal and bacterial infections.
bioRxiv · Mar 6, 2025 · PreprintImmunology