Is synuclein aggregation a derived or ancestral trait? Ancestral sequence reconstruction uncovers stepwise evolution of synuclein aggregation
Andrew Sam, Seungwoo Lee, Jordan Elliott, Emma Larson, Abdullah Naiyer, Jonathan K. Williams, Jean Baum
This study uses ancestral sequence reconstruction to show that synuclein aggregation evolved progressively, with fibril formation emerging in an ancestral node and being suppressed in beta-synuclein.
bioRxiv · Sep 27, 2025 · PreprintBiophysics