eIF4E and Ezrin cooperate in pseudopods to drive a localized migratory translation program in acute myeloid leukemia
Biljana Čuljković, Leandro Marcelo Martinez, Naiyu Shi, Alyssa D. Retiz, Samuel Perron, Aksharh Thambipillai, Caleb M. Embree, Winnie Yip, Vicenta Trujillo-Alonso, Emma Lassman, Marysol Chu Carty, Kata Alilovic, Sébastien Carreno, Gail J. Roboz, Mónica L. Guzmán, Katherine L. B. Borden
In acute myeloid leukemia, Ezrin binds eIF4E and anchors active ribosomes in pseudopods for local translation of CD44 and hyaluronan pathway proteins; eIF4E loss impairs mouse engraftment.
bioRxiv · Oct 2, 2026 · PreprintCancer Biology✦ In-depth digest