Reprogramming the Rossmann Fold Signature Motif Creates Orthogonal Redox Biocatalysts
Yu Ping, Jin Young Kim, Minh-Anh L. Dinh, Emma Luu, Suphanida Worakaensai, Shiding Zhang, William B. Black, Emma Monge, Hans Jefferson C. Ng, Sean Perea, Yulai Zhang, Youtian Cui, Edward J. King, Justin B. Siegel, Han Li
The paper reprograms the Rossmann fold motif to create NMN+-specific enzymes that avoid NAD(P)/H interactions, achieving high specificity and productivity in biotransformation.
Nature Communications · Sep 12, 2026Peer-reviewedMolecular Biology