Machine learning-guided olivetolic acid cyclase engineering enables tailored cannabinoid biosynthesis in yeast
Nathaniel Blalock, Joseph W. LaMattina, Emma Monge, Raymond Tran, Audrey E Louie, Jun Urano, Spiros Kambourakis, Russell S. Komor, Philip A. Romero
This paper uses machine learning to engineer olivetolic acid cyclase in yeast, enhancing cannabinoid production and selectivity.
bioRxiv · Jun 17, 2026 · PreprintBioengineering