Copper induces p53 unfolding in cancer cells, resulting in invasion and chemoresistance
Yannick von Grabowiecki, Steven J Bell, Hannah L Richards, Ellie J Massey, Zoe Newson, Emma Tarrant, Matthew S Morrison, Melanie Galvin, Kathryn Simpson, John P. C. Le Quesne, Lydia Aschauer, Patricia A. J. Muller
The paper shows copper induces p53 unfolding in cancer cells, leading to invasion and chemoresistance, with partial restoration by the chelator Trien.
bioRxiv · Nov 7, 2024 · PreprintCancer Biology