Kathryn Simpson

This paper introduces a 3D imaging pipeline to detect functionally perfused vasculogenic mimicry in mouse tumor models, providing evidence of its presence and functionality.

This study shows circulating tumor cells shed shearosome extracellular vesicles in capillary bifurcations, which activate endothelial and immune cells and contribute to pre-metastatic niche formation.

The paper identifies ATOH1 as a pro-metastatic oncogenic driver in SCLC by showing its role in cell survival and metastasis suppression upon depletion.

The paper shows copper induces p53 unfolding in cancer cells, leading to invasion and chemoresistance, with partial restoration by the chelator Trien.