OPA1 controls mitochondrial dysfunction-driven liver fibrosis in MASLD
Xinting Yu, Pinzhu Huang, Arvo Justice, Aaron Hakim, Yoshiko Nanki, Zaur Abilov, Edward B. O’Neill, Jerry Cruz Rodriguez, Enzo Cabrera, Marla Sagatelian, Chandra Sekhar Uma Shankar, Brenda R. Flam, Kawtar Al Khalloufi, Hiromi Sesaki, 荣世松, Yury V. Popov
The paper identifies OPA1 as a key regulator of liver fibrosis in MASLD by linking mitochondrial dysfunction to fibrotic responses through mito-DAMP release and hepatic stellate cell activation.
bioRxiv · Sep 27, 2026 · PreprintGenetics