Deciphering Cellular Ecosystems Driving Tumor Progression and Immune Escape from Spatial Transcriptomics and Single-Cell with COMPOTES
Loïc Herpin, Anaïs Chossegros, Roberta Codato, Josep Monserrat Sanchez, Jean El Khoury, Simon Grouard, Valérie Ducret, Alex J. Cornish, Baptiste Gross, Elodie Pronier, Caroline Hoffmann, Alberto Romagnoni, Eric Durand, Almudena Espín-Pérez, Quentin Bayard
The paper introduces a machine-learning method to identify recurrent cell-cell communication patterns across tumor samples using spatial transcriptomics and single-cell data, revealing key immune and genetic programs in bladder cancer.
bioRxiv · Oct 27, 2025 · PreprintBioinformatics