Identification of non-covalent inhibitors for the atypical peroxiredoxin PRDX5 as a therapeutic strategy in malignant pleural mesothelioma
Josep Monserrat, Floriane Montanari, Victor Laurent, Pierre‐Benoit Ancey, Nicolas Jean, Cécilia Jeannu, Guimin Wang, Genshu You, Qiancheng Shen, Alice Mac Kain, Yacine Barèche, Loïc Herpin, Nadia Jeremiah, Roberta Codato, Alberto Romagnoni, , Elodie Pronier
The paper identifies non-covalent inhibitors of PRDX5, a protein upregulated in MPM, through a machine learning guided pipeline and biochemical validation, suggesting it as a therapeutic target.
bioRxiv · May 15, 2026 · PreprintCancer Biology