FICD deficiency protects mice from hypertrophy-induced heart failure via BiP-mediated activation of the UPRER and ER-phagy
Shannon M. Lacy, Rebecca J. Taubitz, Nicholas D. Urban, Samantha N. Turowski, Eric N. Primack, Eric D. Smith, Adam S. Helms, Daniel E. Michele, Matthias C. Truttmann
This study shows that FICD deficiency protects mice from heart failure by enhancing BiP-mediated UPRER and ER-phagy under stress.
Journal of the American Heart Association · Aug 18, 2025Peer-reviewedCell Biology