PARP1 and PARP2 are dispensable for DNA repair by microhomology-mediated end-joining during mitosis.
Raquel Ortega, Erin Taylor, Sophie M. Whitehead, Thomas Danhorn, Benjamin Guy Bitler, Nausica Arnoult
This study shows PARP1 and PARP2 are not required for MMEJ during mitosis, challenging previous assumptions and supporting combinatorial PARPi/MMEJi therapy in HR-deficient cancers.
bioRxiv · Jun 9, 2025 · PreprintMolecular Biology