An IL-34-IGF-1 inflammatory axis fuels KRAS-mutant lung cancer progression
Jaroslav Žák, Hui Chen, Erpei Wang, Patrick Ozark, Giuliana P. Mognol, MATTHEW Dae-Young PARK, Nadine Fournier, Priyanka Chaudary, Jingjing Hu, Ryan M. Shepard, Anghesom Ghebremedhin, Marc A. Paradise, Jason Rivera, William J Harris, Zihan Xu, , Judith A. Varner
This study identifies an IL-34-IGF-1 axis between macrophages and KRAS-mutant lung tumor cells that promotes tumor progression and poor survival.
bioRxiv · Jul 15, 2026 · PreprintCancer Biology