Lightweight open-source fine-tuning of SAM2 enables domain-specific microscopy segmentation
Etash Bhat, Sharvaa Selvan, Sonia Okekenwa, Zareh Dechkounian, Vivian Lin, Mariko Nakano-Miyatake, Mitul Saha, Yuyu Song
This paper introduces a lightweight, open-source method to fine-tune SAM2 for microscopy segmentation, achieving high accuracy with small datasets and cross-domain generalization.
bioRxiv · Nov 8, 2025 · PreprintCell Biology