Author

Ethan Crouse

Broad InstitutePrimary ORCID profile (0009-0004-8971-7792 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Ethan CrouseiD1 paper · Brandeis University

Biology Disciplines

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Neuroscience· 2 Cell Biology· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

Ralda NehmeiD· 4 shared Derek Hawes· 2 shared Lindy E. BarrettiD· 2 shared Matthew TegtmeyeriD· 2 shared Samouil L. FarhiiD· 2 shared Steven A. McCarrolliD· 2 shared Vera ValakhiD· 2 shared Adrianna MaglieriiD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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4 shared papersNeuroscience

Ralda NehmeORCID

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4 papers

Recent·Most cited

Gene editing in "cell villages" enables exploring disease-relevant mutations in many genetic backgrounds

Rachel A. Battaglia, Sonia Bolshakova, Ilinca Mazureac, Dhara Liyanage, Noah L. Pettinari, Autumn Johnson, Ethan Crouse, Sartaj Habib, Isabel Flessas, Ajay Nadig, Derek Hawes, Matthew Tegtmeyer, Caroline Becker, Sulagna Dia Ghosh, Giulio Genovese, , Ralda Nehme

The paper uses village editing to study how genetic backgrounds affect the impact of schizophrenia-associated mutations in human neurons.

bioRxiv · Nov 8, 2025 · PreprintCell Biology

A foundational neuronal protein network model unifying multimodal genetic, transcriptional, and proteomic perturbations in schizophrenia.

Greta Pintacuda, Yu-Han H. Hsu, Petra Páleníková, Ugne Dubonyte, Nadine Fornelos, Miao Chen, Daya Mena, Julia C. Biagini, Travis Botts, Makayla Martorana, Danzel Rebelo, Joshua Ching, Ethan Crouse, Hilena Gebre, Xian Adiconis, , Kasper Lage

The paper identifies three neuron-specific schizophrenia protein networks enriched for genetic and transcriptional perturbations and validates their disruption in 22q11.2 deletion carriers.

medRxiv · May 2, 2025 · PreprintGenetic & Genomic Medicine

Robust self-supervised denoising of voltage imaging data using CellMincer

Brice Wang, Tianle Ma, Theresa Chen, Trinh Nguyen, Ethan Crouse, Stephen J. Fleming, Alison Walker, Vera Valakh, Ralda Nehme, Evan W. Miller, Samouil L. Farhi, Mehrtash Babadi

CellMincer is a self-supervised deep learning method for denoising voltage imaging data, achieving significant noise reduction and improved functional phenotype separation.

npj Imaging · Dec 4, 2024Peer-reviewedNeuroscience

Robust induction of functional astrocytes using NGN2 expression in human pluripotent stem cells

Martin H. Berryer, Matthew Tegtmeyer, Loïc Binan, Vera Valakh, Anna J. Nathanson, Darina Trendafilova, Ethan Crouse, Jenny A. Klein, Daniel Meyer, Olli P. H. Pietiläinen, Francesca A. Rapino, Samouil L. Farhi, Lee L. Rubin, Steven A. McCarroll, Ralda Nehme, Lindy E. Barrett

This study develops a rapid, scalable method to generate functional human astrocytes from pluripotent stem cells using NGN2 induction, showing high homogeneity and disease relevance.

iScience · May 30, 2023Peer-reviewedNeuroscience