Lee L. Rubin

The paper identifies signaling pathways that drive the differentiation of brain endothelial cells from hiPSCs in vitro.

The paper uses isogenic cortical organoids to identify variant-specific pathogenic pathways in Alzheimer's disease and demonstrates targeted interventions that restore neuronal survival.

The paper shows that depleting the gut microbiome in aged mice rejuvenates the brain by improving vascular density, myelination, neurogenesis, and reducing inflammation.

The paper uses a chemical genetic approach with induced pluripotent stem cells to screen for compounds affecting SMA neuronal gene expression, generating a queryable dataset of transcriptional profiles.

This paper develops a human iPSC-derived motor neuron-myogenic coculture platform to study NMJ innervation after axon injury and in SMA, showing blebbistatin enhances NMJ reinnervation and confirming reduced NMJ function in SMA patient-derived neurons.

The paper uses ER stressors in ALS patient-derived motor neurons to identify druggable targets that protect against degeneration.

This study develops a rapid, scalable method to generate functional human astrocytes from pluripotent stem cells using NGN2 induction, showing high homogeneity and disease relevance.

The paper combines epidemiological pesticide exposure data with iPSC-derived dopaminergic neuron screening to identify and classify pesticides linked to Parkinson's disease.

The paper develops an automated high-content synaptic phenotyping platform in human neurons and astrocytes, identifying BET inhibitors as key regulators of synapse assembly.

This study identifies GSDME as a mediator of mitochondrial damage and axon loss in neurodegenerative diseases, showing its role in ALS and FTD models.

This study uses single-cell transcriptomics to show that heterochronic parabiosis alters aging signatures in multiple brain cell types, with endothelial cells showing significant transcriptional changes.

The paper shows that inhibiting SIRT1 with modRNA-enhanced Fezf2 expression improves SCPN/corticospinal neuron differentiation from mES cells.

This study uses single-cell transcriptomics to analyze aged mouse brains, identifying cell-type-specific aging signatures and highlighting molecular processes like ribosomal biogenesis.