Small Molecule Regulation of CLOCK:BMAL1 DNA Binding Activity
Diksha Sharma, Soumendu Boral, Ethen West, McClain Kressman, Irene C. Franco, Carlos A. Amezcua, Hsiau‐Wei Lee, Denize C. Favaro, Kevin H. Gardner, Carrie L. Partch
This study identifies small molecules that bind to the PAS-A domain of CLOCK and NPAS2, stabilizing the domain and reducing DNA binding affinity of CLOCK:BMAL1.
bioRxiv · Oct 22, 2026 · PreprintBiochemistry