Acute Myeloid Leukemia Relapse after Bromodomain Inhibitor Treatment or Chemotherapy is Characterized by Myc-Ras Transcriptional Remodeling
Benjamin J. Huang, Jeevitha D’Souza, Alexa Rane Batingana, Max Harris, Xinyue Wang, Eugene Hwang, Anica M. Wandler, Michael R. Burgess, Qing Li, Soheil Meshinchi, Gideon E. Bollag, Kevin Shannon
This study shows that AML relapse after BET inhibitor or chemotherapy involves Myc-Ras transcriptional changes, highlighting transcriptional plasticity in relapsed leukemias.
bioRxiv · Nov 13, 2025 · PreprintCancer Biology