Lipocalin-2-expressing red pulp macrophages link ischemic stroke to systemic immune reprogramming in mice and humans
Alexandra Lucaciu, Patrick Wurzel, Stine Rytz Rasmussen, Eva Lueckhoff, Franziska Mayser, Jiffin Benjamin, Roxane‐Isabelle Kestner, Verena K. Haas, Lisa Sophie Huber, Deepthi Bevara, Nico Kraus, Melanie Glueck, Karen R. Gertz, Raphael Raspe, Sethuraman Subramanian, , Rajkumar Vutukuri
Splenic Lcn2 is induced biphasically after mouse stroke and localizes to red pulp macrophages; recombinant LCN2 induces T cell and monocyte hyporesponsiveness and monocyte phagocytosis-ROS uncoupling, with human spleen support.
bioRxiv · Oct 5, 2026 · PreprintImmunology✦ In-depth digest