Author

F. A. Bozza

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:drug response / drug discovery· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

C. Q. Sacramento· 5 shared C. S. de Freitas· 5 shared M. Mattos· 5 shared N. Fintelman-Rodrigues· 5 shared P. T. Bozza· 5 shared T. M. L. Souza· 5 shared A. C. Ferreira· 4 shared J. R. Temerozo· 4 shared

Activity by Year

2020-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

5 shared papersImmunology

C. Q. Sacramento

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Macrophages undergo necroptosis during severe influenza A infection and contribute to virus-associated cytokine storm

A. C. Ferreira, C. Q. Sacramento, F. S. Pereira-Dutra, N. Fintelman-Rodrigues, P. P. Silva, M. Mattos, C. S. de Freitas, A. Marttorelli, G. R. de Melo, M. C. Macedo, I. G. Azevedo-Quintanilha, A. S. Carlos, J. V. Emidio, C. C. Garcia, P. T. Bozza, , T. M. L. Souza

This study shows that IAV or HA induces necroptosis in macrophages, contributing to cytokine storm and lung injury, and that anti-TNF treatment prevents these effects.

bioRxiv · Apr 20, 2022 · PreprintImmunology

Atazanavir inhibits SARS-CoV-2 replication and pro-inflammatory cytokine production

N. Fintelman-Rodrigues, C. Q. Sacramento, C. Ribeiro Lima, F. Souza da Silva, A. Ferreira, M. Mattos, C. S. de Freitas, V. Cardoso Soares, S. da Silva Gomes Dias, J. R. Temerozo, M. Miranda, A. R. Matos, F. A. Bozza, N. Carels, C. Roberto Alves, , T. M. L. Souza

This study shows that atazanavir inhibits SARS-CoV-2 replication and reduces pro-inflammatory cytokine production in vitro.

Antimicrobial Agents and Chemotherapy · Sep 21, 2020Peer-reviewedMicrobiology

Lipid droplets fuel SARS-CoV-2 replication and production of inflammatory mediators

S. S. Gomes Dias, V. S. Cardoso, A. C. Ferreira, C. Q. Sacramento, N. Fintelman-Rodrigues, J. R. Temerozo, L. Teixeira, E. A. Barreto, M. Mattos, C. S. de Freitas, I. Azevedo-Quintanilha, P. P. A. Manso, E. D. Hottz, C. R. R. Pao, D. C. Bou-Habib, , P. T. Bozza

This study shows that lipid droplets support SARS-CoV-2 replication and inflammatory mediator production, with DGAT-1 inhibition reducing viral replication and inflammation.

bioRxiv · Aug 22, 2020 · PreprintImmunology

VIP plasma levels associate with survival in severe COVID-19 patients, correlating with protective effects in SARS-CoV-2-infected cells.

J. R. Temerozo, C. Q. Sacramento, N. Fintelman-Rodrigues, C. R. R. Pao, C. S. de Freitas, S. d. S. G. Dias, A. C. Ferreira, M. Mattos, V. C. Soares, L. Teixeira, I. G. de Azevedo-Quintanilha, E. D. Hottz, P. Kurtz, F. A. Bozza, P. T. Bozza, , D. C. Bou-Habib

The paper shows elevated VIP plasma levels in severe COVID-19 patients correlate with survival and protective effects against SARS-CoV-2 in vitro.

bioRxiv · Jul 25, 2020Immunology

The in vitro antiviral activity of the anti-hepatitis C virus (HCV) drugs daclatasvir and sofosbuvir against SARS-CoV-2

C. Q. Sacramento, N. Fintelman-Rodrigues, J. R. Temerozo, A. d. P. D. Da Silva, S. da Silva Gomes Dias, A. C. Ferreira, C. d. S. da Silva, M. Mattos, C. R. R. Pao, C. S. de Freitas, V. Cardoso Soares, L. V. B. Hoelz, T. V. A. Fernandes, F. S. C. Branco, M. M. Bastos, , T. M. L. Souza

This study evaluates the antiviral activity of daclatasvir and sofosbuvir against SARS-CoV-2 in vitro, showing inhibition of viral replication and associated pathologies.

bioRxiv · Jun 15, 2020 · PreprintMicrobiology