M. Miranda

Investigating Novel Streptomyces Bacteriophage Endolysins as Potential Antimicrobial Agents

The paper identifies three Streptomyces phage endolysins with PG-degrading activity and antimicrobial potential against ESKAPE bacteria, with LL35lys showing low MIC against Gram-positive strains.

Dichotomy of neutralizing antibody, B cell and T cell responses to SARS-CoV-2 vaccination and protection in healthy adults

The paper identifies four patterns of SARS-CoV-2 vaccine responses, including broad and narrow responders, and links broad responder traits to longer infection-free time after vaccination.

The potential of Senicapoc, a KCNN4 inhibitor, for the prevention and treatment of breast cancer

This study investigates Senicapoc, a KCNN4 inhibitor, and finds it delays mammary tumor development and slows tumor growth in mouse models, suggesting potential for breast cancer prevention and treatment.

Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies

This study designs synthetic oligomeric ligands to modulate FGFR signaling and shows their impact on vascular cell fate decisions.

A novel image-based approach for soybean seed phenotyping using machine learning techniques

This paper develops an image-based machine learning framework for soybean seed phenotyping, achieving high accuracy in segmentation and prediction of hundred-seed weight.

Metabolic profiling of drought tolerance: revealing how citrus rootstocks modulate plant metabolism under varying water availability

This study investigates how Rangpur lime rootstocks modulate citrus metabolism under drought, identifying metabolic changes linked to drought tolerance.

Acute and chronic physical activity improve spatial pattern separation in humans

This study shows that acute and chronic physical activity enhances spatial pattern separation in humans, improving the ability to distinguish similar memories.

The response to drought-stressed host plants varies among herbivorous mite populations from a climate gradient

This study examines how drought stress affects life history traits of Tetranychus urticae mites from different climates, finding that origin climate influences their response to drought.

Dopamine modulates adaptive forgetting in medial prefrontal cortex

This study shows that dopamine D1 receptors in the medial prefrontal cortex are essential for retrieval-induced forgetting in rats, modulating which memories are retained based on behavioral goals.

Epigenome erosion drives neural crest-like phenotypic mimicry in triple-negative breast cancer and other SOX10+ malignancies

The paper identifies SOX10 expression in TNBC and other SOX10+ malignancies, linking it to epigenome erosion and neural crest-like phenotypic mimicry through promoter hypomethylation.

A robust method of nuclei isolation for single-cell RNA sequencing of solid tissues from the plant genus Populus

The paper presents a method to isolate nuclei from plant tissues for scRNA-seq, overcoming limitations of protoplast isolation in complex tissues.

Atazanavir inhibits SARS-CoV-2 replication and pro-inflammatory cytokine production

This study shows that atazanavir inhibits SARS-CoV-2 replication and reduces pro-inflammatory cytokine production in vitro.

A semi-automated method for measuring xylem vessel length distribution

This paper introduces a semi-automated method to measure xylem vessel length distribution using a Pneumatron device and software, enabling faster and more efficient analysis.

Oral feeding with probiotic Lactobacillus rhamnosus attenuates cigarette smoke-induced COPD in C57Bl/6 mice: Relevance to inflammatory markers in human bronchial epithelial cells

This study shows that probiotic Lactobacillus rhamnosus reduces inflammation in COPD mice and human bronchial cells exposed to cigarette smoke.

Crystal violet structural analogues identified by in silico drug repositioning present anti-Trypanosoma cruzi activity through inhibition of proline transporter TcAAAP069

This paper identifies crystal violet structural analogues with anti-Trypanosoma cruzi activity by inhibiting the proline transporter TcAAAP069 and shows synergistic effects with benznidazole.