Protein substrates engage the lumen of O-GlcNAc transferase's tetratricopeptide repeat domain in different ways
C. M. Joiner, F. A. Hammel, J. Janetzko, S. Walker
The paper shows that OGT's TPR domain lumen uses asparagine and aspartate ladders to control substrate glycosylation, with C-terminal sites bypassing lumenal binding.
bioRxiv · Dec 22, 2020Biochemistry