Membrane phosphoinositides stabilize GPCR-arrestin complexes and offer temporal control of complex assembly and dynamics
J. Janetzko, R. Kise, B. Barsi-Rhyne, D. H. Siepe, F. M. Heydenreich, M. Masureel, K. Kawakami, K. C. Garcia, M. Von Zastrow, A. Inoue, B. K. Kobilka
This study identifies membrane phosphoinositides as regulators of GPCR-arrestin complex dynamics, showing they stabilize complexes and enable temporal control of receptor signaling and recycling.
bioRxiv · Oct 9, 2021Biochemistry