Biosynthesis of pleuromutilin congeners using an Aspergillus oryzae expression platform
F. Alberti, K. Khairudin, J. A. Davies, S. Sangmalee, C. L. Willis, G. D. Foster, A. M. Bailey
This study identifies two shunt pathways in pleuromutilin biosynthesis using Aspergillus oryzae, leading to three novel congeners with varied antimicrobial activity.
bioRxiv · Dec 3, 2022 · PreprintMicrobiology