D. Kaur

Identification of Juglone, a "first-in-class" inhibitor of the human glutathione degrading enzyme, ChaC1, using yeast-based high throughput screens

This study identifies juglone as a first-in-class inhibitor of ChaC1 using yeast-based screens, showing it inhibits both ChaC1 and ChaC2 with an IC50 of 8.7 μM through a novel mechanism.

Antibiotic resistance alters the ability of Pseudomonas aeruginosa to invade the respiratory microbiome

This study shows antibiotic resistance in Pseudomonas aeruginosa can both help and hinder its ability to invade respiratory microbiomes, depending on the commensal microbes involved.

Untangling the Role of Pathobionts from Bacteroides Species in Inflammatory Bowel Diseases

This study shows that Bacteroides fragilis from UC patients promotes colitis in genetically susceptible mice, suggesting a role for pathobionts in IBD.

GWAS identifies candidate genes controlling adventitious rooting in Populus trichocarpa

This study uses GWAS to identify 277 candidate genes associated with adventitious rooting in Populus trichocarpa, highlighting roles in hormone signaling, cell division, and reactive oxygen species.

GWAS identifies candidate regulators of in planta regeneration in Populus trichocarpa

This study uses GWAS to identify candidate genes regulating in planta regeneration in Populus trichocarpa, finding over 200 genes involved in cell adhesion, stress signaling, and hormone pathways.

Robust high-throughput phenotyping with deep segmentation enabled by a web-based annotator

This paper introduces a high-throughput plant phenotyping system with a GUI and SGIOS algorithm to streamline training data generation and improve GWAS for trait variation analysis.

Transcriptomic analysis of ribosome biogenesis and pre-rRNA processing during growth stress in Entamoeba histolytica

The paper identifies ribosome biogenesis factors in Entamoeba histolytica and shows their differential regulation during stress, revealing unique features compared to yeast and humans.

Proton egress pathway during the S1 to S2 transition of the Oxygen Evolving Complex ofPhotosystem II

The paper uses computational methods to analyze proton transfer pathways during the S1 to S2 transition of the Oxygen Evolving Complex in Photosystem II, identifying the broad channel as the most likely proton exit route.

Pathophysiological regulation of lung function by the free fatty acid receptor FFA4

This study shows that activating FFA4 reduces airway resistance in mouse models of inflammation and human lung tissue, suggesting it could be a therapeutic target for asthma and COPD.

Engineering isoprenoid quinone production in yeast

This paper engineers a yeast strain to overproduce isoprenoid quinones, achieving a four-fold increase in coenzyme Q6 production.

Genome wide association with quantitative resistance phenotypes in Mycobacterium tuberculosis reveals novel resistance genes and regulatory regions

This study identifies novel resistance genes and regulatory regions in Mycobacterium tuberculosis using genome-wide association analysis of drug resistance phenotypes.