Autophagy modulation enhances enzyme replacement therapy response in Fabry disease
L. Abily-Donval, F. Barbey, S. Torre, C. Lesueur, M. Chevrier, T. Pereira, C. Pilon, S. Marret, A. Tebani, S. Bekri
This study shows that autophagy inhibition improves enzyme replacement therapy effectiveness in Fabry disease by enhancing exogenous enzyme trafficking to lysosomes.
bioRxiv · Apr 26, 2021 · PreprintBiochemistry