Top-Down Ion Mobility Separations of Isomeric Proteoforms
F. Berthias, H. A. Thurman, G. Wijegunawardena, H. Wu, A. Shvartsburg, O. N. Jensen
This paper demonstrates baseline IMS resolution of intact isomeric proteoforms, specifically acetylated H4 histones, using trapped IMS on a Bruker TIMS/ToF platform.
bioRxiv · Jul 23, 2022Biochemistry