H. Wu

An organoid co-culture model for probing systemic anti-tumor immunity in lung cancer

The paper develops a co-culture model of lung cancer organoids and peripheral blood mononuclear cells to study systemic anti-tumor immunity and predict immunotherapy outcomes.

Reversible disulfide bond crosslinks as tunable levers of phase separation in designer biomolecular condensates.

This study investigates the role of cysteine residues in biomolecular condensates, showing they function as covalent nodes that tune phase separation through redox-sensitive disulfide bonds.

Carbon Dots and Single-walled Carbon Nanotubes Enhances Maize Shading Stress Tolerance

This study shows that carbon dots and single-walled carbon nanotubes improve maize photosynthesis and growth under shading stress by reducing oxidative damage and enhancing chloroplast function.

Non-muscle myosin 2 can incorporate into established filaments in cells without an assembly competence domain

This study shows that non-muscle myosin 2A lacking the ACD can co-assemble with existing filaments, indicating the ACD is not required for association with established filaments.

NSP4 mutation T492I drives rapid evolution of SARS-CoV-2 toward Omicron

This study shows that the NSP4 T492I mutation increases SARS-CoV-2 mutation rates and accelerates the emergence of Omicron-like mutations.

Elucidating the kinetic and thermodynamic insight into regulation of glycolysis by lactate dehydrogenase and its impact on tricarboxylic acid cycle and oxidative phosphorylation in cancer cells

This study investigates how lactate dehydrogenase (LDH) regulates glycolysis, TCA cycle, and oxidative phosphorylation in cancer cells through kinetic and thermodynamic mechanisms, showing that LDH inhibition disrupts metabolic pathways and induces cell death under hypoxia.

Integrated single-cell RNA-seq analysis revealed PTN secreted by fibroblasts acting on itself and macrophages via SDC4 ligand in myocardial hypertrophy

The paper identifies PTN secreted by fibroblasts acting on itself and macrophages via SDC4 in myocardial hypertrophy using scRNA-seq and experimental validation.

Lipid droplets restrict phagosome formation during Candida challenge

This study shows that lipid droplets restrict phagosome formation in macrophages during Candida infection, protecting cells from death and offering a potential drug target.

Structure-Based Design of a Highly Immunogenic, Conformationally Stabilized FimH Antigen for a Urinary Tract Infection Vaccine

The paper designs a conformationally stabilized FimH antigen for a UTI vaccine, showing improved immunogenicity and structural similarity to native FimH.

PRR adjuvants restrain high stability peptides presentation on APCs

This study shows adjuvants like MPLA and CpG reduce high-stability peptide presentation on APCs, shifting T-cell immunodominant epitope responses.

Single-Cell multiomics reveals ENL mutation perturbs kidney developmental trajectory by rewiring gene regulatory landscape

This study shows that an ENL mutation disrupts kidney development by altering gene regulation, leading to developmental defects and early death in mice, and suggests potential therapeutic strategies.

Androgen receptor activity inversely correlates with immune cell infiltration and immunotherapy response across multiple cancer lineages

The paper examines the relationship between androgen receptor activity and immune cell infiltration, showing that lower AR activity correlates with increased immune activity and better immunotherapy response across multiple cancers.

Modulation of host signalling pathways reveal a major role for Wnt signalling in the maturation of Plasmodium falciparum liver schizonts

The paper identifies Wnt signaling as critical for Plasmodium falciparum liver schizont maturation by using a novel medium to maintain hepatocyte functionality and analyze host-parasite interactions.

Functional selection in SH3-mediated activation of the PI3 kinase

This study identifies how SH3 domains activate PI3K by engaging in tertiary interactions with p85, revealing a mechanism for controlling activation through functional selection.

StomaVision: stomatal trait analysis through deep learning

StomaVision automates stomatal trait analysis from micrographs, revealing physiological responses to heat stress across plant species.

Genetic purging of strongly deleterious mutations underlies black-necked crane's unusual escape from an extinction vortex

This study shows black-necked cranes rapidly recovered from a population bottleneck through genetic purging of deleterious mutations, escaping an extinction vortex.

Structural basis for CCR6 modulation by allosteric antagonists

This paper presents two inactive CCR6 structures bound to allosteric antagonists, revealing structural insights into CCR6 inhibition and its implications for drug discovery.

Multiplexed transcriptomic analyses of the plant embryonic hourglass

The paper uses spatial transcriptomics to compare gene expression patterns in plant embryos, revealing a phylotypic hourglass pattern similar to animals, indicating an ancient conserved mechanism for morphological development.

Forage conservation is a neglected nitrous oxide source

This study investigates N2O emissions from forage conservation and finds it could be a significant source, with chlorate reducing emissions but other factors having no effect.

Structural diversity and clustering of bacterial flagellar outer domains

The paper analyzes flagellar outer domains in bacterial species, revealing structural diversity and identifying new clusters of flagellin structures.

In-Space Fabrication of Janus Base Nano-Matrix for Improved Assembly and Bioactivities

The paper demonstrates the fabrication of DNA-inspired Janus base nanomaterials in space, showing their potential for in-space manufacturing.

The protective roles of Eugenol on type 1 diabetes mellitus through NRF2 mediated oxidative stress pathway

This study investigates the protective effects of eugenol on type 1 diabetes mellitus by activating the NRF2 pathway, reducing oxidative stress and apoptosis in pancreatic β cells.

Thymic dendritic cell-derived IL-27p28 promotes the establishment of functional bias against IFN-γ production in newly generated CD4+ T cells through STAT1-related epigenetic mechanisms

Dysregulation of macrophage lipid metabolism underlies intracellular bacterial neuroinvasion

This study identifies a CD36+ macrophage subpopulation that facilitates intracellular bacterial brain invasion through lipid metabolism dysregulation and glucose intervention.

Genetic regulation and targeted reversal of lysosomal dysfunction and inflammatory sterol metabolism in pulmonary arterial hypertension

The paper identifies NCOA7's role in lysosomal function and inflammatory sterol metabolism in PAH, showing its deficiency exacerbates disease through oxysterol/bile acid generation.

Interplay Between FoxM1 and Dab2 Promotes Endothelial Cell Responses in Diabetic Wound Healing

This study identifies Dab2 and FoxM1 as key regulators of endothelial dysfunction in diabetes, showing that restoring Dab2 improves angiogenesis and wound healing.

Granulosa cell-layer stiffening prevents the granulosa cells from escaping the post-ovulatory follicle

The paper shows that granulosa cell-layer stiffening, driven by focal adhesion assembly and LH signaling, prevents granulosa cells from escaping the post-ovulatory follicle.

Architecture of intact mammalian pyruvate dehydrogenase complex revealed by in-situ structural analysis

This study reveals the in-situ architecture of the mammalian pyruvate dehydrogenase complex using cryo-electron tomography, showing dynamic interactions and variable peripheral compositions.

Discovery of SARS-CoV-2 papain-like protease (PLpro) inhibitors with efficacy in a murine infection model

This study identifies potent SARS-CoV-2 PLpro inhibitors using machine learning, showing efficacy in a mouse model of COVID-19.

TDP43 aggregation at ER-exit sites impairs ER-to-Golgi transport

The paper identifies TDP43 aggregation at ER-exit sites as a cause of impaired ER-to-Golgi transport in ALS.