Transcytosis maintains CFTR apical polarity in the face of constitutive and mutation-induced basolateral missorting
A. Bidaud-Meynard, F. Bossard, A. Schnur, R. Fukuda, G. Veit, H. Xu, G. L. Lukacs
The paper shows that transcytosis helps maintain CFTR apical polarity by retrieving basolateral CFTR and counteracting missorting caused by mutations or loss of NHERF1 interaction.
bioRxiv · Oct 20, 2018Cell Biology