A. Bidaud-Meynard

This study shows that AP-1B controls both proliferation and differentiation in the mouse intestine through distinct pathways involving polarity, YAP, and EGFR/mTOR.

This study shows that V0-ATPase depletion causes MVID-like microvillus atrophy in mouse intestinal organoids without affecting apical trafficking.

The paper identifies a V0-ATPase-dependent apical trafficking pathway essential for intestinal epithelial polarity and shows its depletion mimics Microvillus inclusion disease defects in C. elegans.

The paper shows that transcytosis helps maintain CFTR apical polarity by retrieving basolateral CFTR and counteracting missorting caused by mutations or loss of NHERF1 interaction.