The PAXFOXO1s trigger fast trans-differentiation of chick embryonic neural cells into alveolar rhabdomyosarcoma with tissue invasive properties limited by S phase entry inhibition
G. GONZALEZ CURTO, A. Der Vartanian, Y. FRARMA, L. Manceau, L. Baldi, S. Prisco, N. ELAROUCI, F. Causeret, M. RIGOLET, F. AURADE, A. DE REYNIES, V. CONTREMOULINS, F. RELAIX, O. FAKLARIS, J. BRISCOE, , V. RIBES
This study shows PAXFOXO1 fusion proteins drive neural cells to become ARMS-like cells but are limited by G1 cell cycle arrest, which can be overcome by CYCLIN D1 or MYCN.
bioRxiv · May 18, 2020 · PreprintCancer Biology