F. Relaix

Transient hypoxia followed by progressive reoxygenation is required for efficient skeletal muscle repair through Rev-ERBalpha modulation

This study shows that transient hypoxia followed by reoxygenation is essential for skeletal muscle repair, mediated by Rev-ERBalpha regulation of myogenesis.

Ambulatory electrocardiographic longitudinal monitoring in dystrophin-deficient dogs identifies decreased Very Low Frequency power as a hallmark of impaired Heart Rate Variability in Duchenne Muscular Dystrophy

Receptor-interacting protein kinase-3 mediates both myopathy and cardiomyopathy in preclinical animal models of Duchenne muscular dystrophy

This study shows that inhibiting necroptosis in dystrophic mice improves cardiac and skeletal muscle function, suggesting necroptosis contributes to DMD-related myopathy and cardiomyopathy.

Interferon-gamma mediates skeletal muscle lesions through JAK/STAT pathway activation in inclusion body myositis

This study shows that IFN-gamma induces skeletal muscle degeneration via JAK/STAT pathway activation in IBM, with ruxolitinib reversing these effects.

A fast Myh super enhancer dictates adult muscle fiber phenotype through competitive interactions with the fast Myh genes

Direct contribution of skeletal muscle mesenchymal progenitors to bone repair

This study shows skeletal muscle mesenchymal progenitors contribute to bone repair by first forming fibrous tissue and then supporting cartilage and bone formation, but fail to do so in polytrauma leading to impaired healing.

The PAXFOXO1s trigger fast trans-differentiation of chick embryonic neural cells into alveolar rhabdomyosarcoma with tissue invasive properties limited by S phase entry inhibition

This study shows PAXFOXO1 fusion proteins drive neural cells to become ARMS-like cells but are limited by G1 cell cycle arrest, which can be overcome by CYCLIN D1 or MYCN.

Single-nucleus RNA-seq and FISH reveal coordinated transcriptional activity in mammalian myofibers

The paper uses snRNA-seq and FISH to show that myonuclei within mammalian myofibers are coordinately expressed, primarily expressing one Myh isoform and showing synchronization early in development.

Alteration of cardiolipin-dependent mitochondrial coupling in muscle protects against obesity

This study identifies Hacd1 as a regulator of mitochondrial membrane composition in muscle, showing that reduced mitochondrial coupling protects against obesity.