High-resolution Molecular Dynamics Simulations of the Pyruvate Kinase Muscle Isoform 1 and 2 (PKM1/2)
Q. Delobelle, T. Jaffrelot-Inizan, O. P. Adjoua, L. Lagardere, F. Celerse, V. Marechal, J.-P. Piquemal
This study uses high-resolution molecular dynamics simulations to analyze PKM1 and PKM2 structural dynamics, revealing new cryptic pockets for antitumoral drug design.
bioRxiv · Jan 7, 2024Biophysics