BiochemistrybioRxivPreprint
A Systematic Approach to the Discovery of Protein-Protein Inter-action Stabilizers
D. N. Kenanova, E. J. Visser, J. M. Virta…·M. R. Arkin
This study uses disulfide tethering to identify small molecule stabilizers of 14-3-3{sigma} phospho-peptide interactions, finding selective and efficacious fragments for four of five client complexes.
DOI 10.1101/2023.01.29.526112