Author

M. R. Arkin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Cell Biology· 2 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:drug response / drug discovery· 5 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. R. Renslo· 2 shared C. Ottmann· 2 shared E. Sijbesma· 2 shared H. R. Vickery· 2 shared J. M. Virta· 2 shared A. C. Thwin· 1 shared A. Gallardo-Godoy· 1 shared A. L. Wang· 1 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersBiochemistry

A. R. Renslo

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Development of a NanoBRET assay for evaluation of 14-3-3σ molecular glues

H. R. Vickery, J. M. Virta, M. Konstantinidou, M. R. Arkin

The paper develops a NanoBRET assay to evaluate molecular glues targeting 14-3-3σ client proteins in living cells, showing EC50 values consistent with in vitro measurements.

bioRxiv · Dec 31, 2023Cell Biology

The p97/VCP adapter UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions

J. R. Braxton, C. R. Altobelli, M. R. Tucker, E. Tse, A. C. Thwin, M. R. Arkin, D. R. Southworth

This study identifies UBXD1 as a p97 ATPase inhibitor and shows how its domains induce structural remodeling and ring opening of the p97 hexamer.

bioRxiv · May 15, 2023 · PreprintBiochemistry

A Systematic Approach to the Discovery of Protein-Protein Inter-action Stabilizers

D. N. Kenanova, E. J. Visser, J. M. Virta, E. Sijbesma, F. Centorrino, H. R. Vickery, M. Zhong, J. R. Neitz, L. Brunsveld, C. Ottmann, M. R. Arkin

This study uses disulfide tethering to identify small molecule stabilizers of 14-3-3{sigma} phospho-peptide interactions, finding selective and efficacious fragments for four of five client complexes.

bioRxiv · Jan 29, 2023 · PreprintBiochemistry

A genetically encoded, pH-sensitive mTFP1 biosensor for probing lysosomal pH

M. Y. Chin, A. R. Patwardhan, K.-H. Ang, A. L. Wang, C. Alquezar, M. Welch, P. T. Nguyen, M. Grabe, A. V. Molofsky, M. R. Arkin, A. W. Kao

The paper develops a genetically encoded pH biosensor, FIRE-pHLy, for lysosomal pH measurement and demonstrates its use in cellular models.

bioRxiv · Nov 4, 2020 · PreprintCell Biology

A multi-dimensional, time-lapse, high content screening platform applied to schistosomiasis drug discovery

S. Chen, B. M. Suzuki, J. Dohrmann, R. Singh, M. R. Arkin, C. R. Caffrey

The paper develops a high-content screening platform to analyze schistosomiasis drug responses and identifies new bioactive compounds.

bioRxiv · Oct 6, 2020 · PreprintMicrobiology

Inhibition and Crystal Structure of the Human DHTKD1-Thiamin Diphosphate Complex

J. Leandro, S. Khamrui, H. Wang, C. Suebsuwong, N. S. Nemeria, K. Huynh, M. Moustakim, C. Secor, M. Wang, T. Dodatko, B. Stauffer, C. G. Wilson, C. Yu, M. R. Arkin, F. Jordan, , S. M. Houten

This study identifies DHTKD1 inhibitors and reports its crystal structure with thiamin diphosphate, revealing how mutations affect its function and stability.

bioRxiv · Jan 20, 2020Biochemistry

Small molecule inhibitors of a human recombination-associated ATPase, RAD54

K. T. Ehmsen, K. K. H. Ang, W. D. Wright, J. L. Davies, Y. Younis, Y. Birman, C. Bryant, A. Gallardo-Godoy, A. R. Renslo, R. J. Neitz, M. R. Arkin, W.-D. Heyer

This study identifies small molecule inhibitors of the human RAD54 ATPase, which is involved in homologous recombination, and evaluates their effects on DNA repair and cancer cell survival.

bioRxiv · Apr 19, 2019 · PreprintBiochemistry

A Liquid Chromatography-Mass Spectrometry Method For Screening Disulfide Tethering Fragments

K. K. Hallenbeck, J. Davies, C. Merron, P. Ogden, E. Sijbesma, C. Ottmann, A. R. Renslo, C. Wilson, M. R. Arkin

The paper refines an LC/MS-based method for screening covalent small-molecule binders to proteins, achieving fast and reliable screening over multiple projects.

bioRxiv · Aug 4, 2017Biophysics