Author

C. Ottmann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 2 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:drug response / drug discovery· 6 Assay:protein structure· 3 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Approach:deep learning· 1

Frequent Co-Authors

L. Brunsveld· 4 shared P. J. Cossar· 3 shared B. Tivon· 2 shared E. J. Visser· 2 shared E. Sijbesma· 2 shared M. R. Arkin· 2 shared M. Wolter· 2 shared N. London· 2 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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4 shared papersBiochemistry

L. Brunsveld

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity.

L. S. Katz, E. J. Visser, K. F. Plitzko, M. Pennings, P. J. Cossar, I. L. Tse, M. Kaiser, L. Brunsveld, C. Ottmann, D. K. Scott

This paper identifies molecular glues that stabilize the ChREBP/14-3-3 complex, protecting beta cells from glucolipotoxicity by preventing ChREBP-mediated dedifferentiation.

bioRxiv · Feb 16, 2024Cell Biology

A simple method for developing lysine targeted covalent protein reagents

R. Gabizon, B. Tivon, R. N. Reddi, M. Van Den Oetelaar, H. Amartely, P. J. Cossar, C. Ottmann, N. London

This paper develops a method to create covalent protein reagents targeting lysine residues using methacrylate esters, demonstrating their effectiveness in binding and stabilizing protein complexes.

bioRxiv · Aug 28, 2023Biochemistry

A Systematic Approach to the Discovery of Protein-Protein Inter-action Stabilizers

D. N. Kenanova, E. J. Visser, J. M. Virta, E. Sijbesma, F. Centorrino, H. R. Vickery, M. Zhong, J. R. Neitz, L. Brunsveld, C. Ottmann, M. R. Arkin

This study uses disulfide tethering to identify small molecule stabilizers of 14-3-3{sigma} phospho-peptide interactions, finding selective and efficacious fragments for four of five client complexes.

bioRxiv · Jan 29, 2023 · PreprintBiochemistry

Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR

L. M. Stevers, M. Wolter, G. Carlile, D. Macdonald, L. Richard, F. Gielkens, D. Thomas, S. K. Chakka, M. L. Peterson, H. Thomas, L. Brunsveld, C. Ottmann

This paper identifies a macrocycle that stabilizes the 14-3-3/CFTR complex, enhancing CFTR membrane localization and activity, particularly for the F508del mutation.

bioRxiv · Jan 3, 2022Biochemistry

Understanding the interaction of 14-3-3 proteins with hDMX and hDM2: a structural and biophysical study

S. Srdanovic, M. Wolter, C. H. Trinh, C. Ottmann, S. L. Warriner, A. J. Wilson

The paper investigates the structural and biophysical interactions between 14-3-3 proteins and hDMX/hDM2, identifying key phosphosites that enable high-affinity binding.

bioRxiv · Dec 17, 2021Biophysics

Covalent Flexible Peptide Docking in Rosetta

B. Tivon, R. Gabizon, B. A. Somsen, P. J. Cossar, C. Ottmann, N. London

The paper introduces CovPepDock, a computational pipeline for covalent peptide docking, and validates it by identifying potent electrophilic peptide binders.

bioRxiv · May 6, 2021Biochemistry

Molecular basis for inhibition of adhesin-mediated bacterial-host interactions through a novel peptide-binding domain

S. Guo, H. Zahiri, C. Stevens, D. Spaanderman, L.-G. Milroy, C. Ottmann, L. Brunsveld, I. Voets, P. Davies

The paper identifies a peptide-binding domain in a bacterial adhesion protein and develops ligands that inhibit its function, suggesting potential for disrupting harmful bacterial-host interactions.

bioRxiv · Nov 18, 2020Microbiology

A Liquid Chromatography-Mass Spectrometry Method For Screening Disulfide Tethering Fragments

K. K. Hallenbeck, J. Davies, C. Merron, P. Ogden, E. Sijbesma, C. Ottmann, A. R. Renslo, C. Wilson, M. R. Arkin

The paper refines an LC/MS-based method for screening covalent small-molecule binders to proteins, achieving fast and reliable screening over multiple projects.

bioRxiv · Aug 4, 2017Biophysics