Regulation of eIF4F complex by the peptidyl prolyl isomerase FKBP7 in taxane-resistant prostate cancer
M. F. GARRIDO, N. J. MARTIN, C. GAUDIN, F. Commo, N. AL NAKOUZI, L. FAZLI, E. DEL NERY, J. Camonis, F. Perez, S. LERONDEL, A. LE PAPE, H. ABOU-HAMDAN, M. Gleave, Y. Loriot, L. DESAUBRY, , A. CHAUCHEREAU
This study identifies FKBP7 as a molecular chaperone that regulates the eIF4F complex in taxane-resistant prostate cancer, and shows that inhibiting eIF4A can overcome resistance.
bioRxiv · Dec 22, 2016Cancer Biology