Author

F. E. Leach

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Organism:C. elegans· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Approach:machine learning (classical)· 1 Assay:metabolomics· 1

Frequent Co-Authors

A. S. Edison· 2 shared A. M. Morse· 1 shared A. Manson· 1 shared A. O. Shaver· 1 shared B. M. Garcia· 1 shared C. K. Asef· 1 shared F. Fernandez· 1 shared G. J. Gouveia· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

A. S. Edison

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Author profile →

2 papers

Recent·Most cited

Role of ugt genes in detoxification and glycosylation of 1-hydroxy phenazine (1-HP) in Caenorhabditis elegans

M. Z. Asif, K. A. Nocilla, L. T. Ngo, M. K. Shah, Y. Smadi, Z. A. Hafeez, M. Parnes, A. Manson, J. Glushka, F. E. Leach, A. S. Edison

This study investigates the role of ugt genes in detoxifying 1-hydroxyphenazine (1-HP) in C. elegans, showing that ugt-23 and ugt-49 mutants are more sensitive to 1-HP and produce fewer derivatives.

bioRxiv · Nov 21, 2023 · PreprintBiochemistry

Ion Mobility for Unknown Metabolite Identification: Hope or Hype?

C. K. Asef, M. Rainey, B. M. Garcia, G. J. Gouveia, A. O. Shaver, F. E. Leach, A. M. Morse, A. S. Edison, L. McIntyre, F. Fernandez

This study evaluates the use of ion mobility-mass spectrometry (IM-MS) for identifying unknown metabolites in complex samples, highlighting challenges in data analysis and instrumentation performance.

bioRxiv · Aug 26, 2022 · PreprintBiochemistry