Molecular and metabolomic characterization of hiPSC-derived cardiac fibroblasts transitioning to myofibroblasts
R. Nagalingam, F. Jayousi, H. Hamledari, D. Hosseini, S. Dababneh, C. Lindsay, R. Klein Geltink, P. Lange, I. M. C. Dixon, R. A. Rose, M. P. Czubryt, G. F. Tibbits
This study shows that passaging hiPSC-derived cardiac fibroblasts activates them to myofibroblasts, involving TGFβ1, Hippo signaling, and mitochondrial metabolism changes.
bioRxiv · Oct 8, 2023Cell Biology