Counterintuitive Binding of Phosphorylated DEP Domain from Dishevelled Protein to Negatively Charged Membranes
F. L. Falginella, M. Drabinova, V. Bryja, R. Vacha
The paper shows phosphorylation of DEP domain alters electrostatic potential but enhances binding to negatively charged PA-rich membranes through hydrogen bonds and ion-mediated interactions.
bioRxiv · Jan 27, 2023 · PreprintBiophysics