Stochastic asymmetric repartition of lytic machinery in dividing human CD8+ T cells generates heterogeneous killing behavior
F. Lafouresse, R. Jugele, S. Mueller, M. Doineau, V. Duplan-Eche, E. Espinosa, M.-P. Puissegur, S. Gadat, S. Valitutti
The paper shows that human CD8+ T cells randomly distribute lytic granules during division, leading to functional heterogeneity in their killing ability.
bioRxiv · Sep 8, 2020Immunology