S. Mueller

Functional characterization of pathway inhibitors for the ubiquitin-proteasome system (UPS) as tool compounds for CRBN and VHL-mediated targeted protein degradation

The paper evaluates diverse ubiquitin pathway inhibitors as controls for CRBN and VHL-mediated protein degradation, assessing their potency and toxicity using the HiBiT system and high content assays.

GABA production induced by imipridones is a targetable and imageable metabolic alteration in diffuse midline gliomas

This study shows imipridones induce GABA accumulation in diffuse midline gliomas, which can be used for non-invasive imaging and therapy.

Perforin-mediated pore formation at the lytic synapse triggers the canonical pyroptotic cell death pathway

This study shows perforin triggers pyroptosis in target cells by activating the NLRP3/caspase-1/gasdermin D pathway, while sustained CTL interaction leads to apoptosis.

Synthesis and evaluation of chemical linchpins for highly selective CK2α targeting

The paper designs and evaluates chemical linchpins targeting CK2α with a novel binding mode combining allosteric and ATP competitive elements, showing high selectivity and low micromolar activity.

Plasma membrane and cytoplasmic compartmentalization: a dynamic structural framework required for pollen tube tip growth

The paper maps plasma membrane and cytoplasmic domains in tobacco pollen tubes to understand tip growth mechanisms.

Perceived biodiversity: is what we measure also what we see and hear?

This study investigates how people perceive visual and acoustic diversity in forests and finds that acoustic perceptions are more strongly linked to actual species richness than visual ones.

Back-pocket optimization of 2-aminopyrimidine-based macrocycles leads to potent dual EPHA2/GAK kinase inhibitors with antiviral activity

The paper optimizes a 2-aminopyrimidine-based macrocycle to create a dual EPHA2/GAK kinase inhibitor with antiviral activity against dengue virus.

Shifting to biology promotes highly efficient iron removal in groundwater filters

This study shows that mild aeration in sand filters promotes biological iron removal, achieving faster oxidation rates and higher water yields compared to intensive aeration.

On the ecology of Acinetobacter baumannii - jet stream rider and opportunist by nature

This study identifies white storks as a model system to explore the ecology of Acinetobacter baumannii, revealing its environmental reservoirs, seasonality, and genetic diversity across Europe.

Development of selective pyridopyrimidin-7(8H)-one-based Mammalian STE20-like (MST3/4) kinase inhibitors

This study develops selective MST3/4 kinase inhibitors and demonstrates their distinct cellular effects compared to MST1/2 inhibition.

Synthesis of pyrazole-based macrocycles leads to a highly selective inhibitor for MST3

The paper designs and synthesizes a macrocyclic inhibitor, JA310, that selectively targets MST3 with high potency and kinome-wide selectivity.

Targeting LC3/GABARAP for degrader development and autophagy modulation

The paper evaluates the druggability of LC3/GABARAP for autophagy modulators and identifies ligands that bind to the HP2 pocket of the LIR docking site.

Discovery of a new activator of Slack potassium channels with robust efficacy in models of histamine-independent and chronic itch

This study identifies compound 6 as a potent Slack potassium channel activator effective in treating histamine-independent and chronic itch without motor side effects.

Polo-like kinase 1 regulates immune synapse assembly and cytotoxic T cell function by driving microtubule dynamics

This study shows that Polo-like kinase 1 (PLK1) is essential for immune synapse (IS) assembly and cytotoxic T cell function by regulating microtubule dynamics during IS formation.

The bigger picture: global analysis of solubilization performance of classical detergents versus new synthetic polymers utilizing shotgun proteomics

This study compares the solubilization performance of synthetic polymers and detergents using shotgun proteomics to extract membrane proteins in native nanodiscs.

PI3K/mTOR is a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma

This study identifies PI3K/mTOR as a targetable genetic dependency in DIPG and demonstrates that combining paxalisib with metformin improves survival in xenograft models.

Spatial transcriptomics maps molecular and cellular requirements for CD4+ T cell-dependent immunity to malaria.

This paper uses spatial transcriptomics to map CD4+ T cell and B cell interactions in the spleen during malaria infection, revealing their localization and molecular requirements for immunity.

Assessment of Immunogenicity and Efficacy of CV0501 mRNA-based Omicron COVID-19 Vaccination in Small Animal Models

This paper evaluates the immunogenicity and efficacy of a bivalent mRNA vaccine CV0501 against Omicron subvariants in animal models, showing robust neutralizing antibodies and reduced viral loads.

HSPA8 chaperone complex drives chaperone-mediated autophagy regulation in acute promyelocytic leukemia differentiation

This study shows that HSPA8 chaperone complex regulates chaperone-mediated autophagy (CMA) during APL differentiation, with CMA downregulation required for neutrophil maturation.

The slow evolving genome of the xenacoelomorph worm Xenoturbella bocki

This study analyzes the genome of Xenoturbella bocki to assess its phylogenetic position and genomic complexity, finding it has a complex genome similar to other bilaterians.

The role of auxiliary domains in modulating CHD4 activity suggests mechanistic commonality between enzyme families

The paper investigates how auxiliary domains in CHD4 modulate its activity, revealing common regulatory mechanisms across chromatin remodelling enzyme families.

Viscoelastic properties of suspended cells measured with shear flow deformation cytometry

This paper introduces a microfluidic method to measure viscoelastic properties of suspended cells using shear flow deformation cytometry and demonstrates cell cycle-dependent rheological behavior.

Fibroblastic reticular cells provide a supportive niche for lymph node-resident macrophages

This study identifies fibroblastic reticular cells (FRCs) as essential for supporting lymph node-resident macrophages through CSF1 and CSF1R signaling.

Proteomics of spatially identified tissues in whole organs

This paper introduces DISCO-MS, a method for spatial proteomics of whole organs, and shows it provides proteomics data comparable to fresh tissues in rodent and human samples.

mRNA Vaccines Induce Rapid Antibody Responses in Mice

This study shows mRNA vaccines induce rapid antibody responses in mice by day 5, outperforming DNA, protein, and adenovirus vaccines for SARS-CoV-2 and HIV-1 antigens.

Impairment of the cellulose degradation machinery enhances fungal virulence but limits reproductive fitness

The paper shows that impairing cellulose degradation in Fusarium oxysporum increases virulence but reduces reproductive fitness.

Biomarker Candidates for Tumors Identified from Deep-Profiled Plasma Stem Predominantly from the Low Abundant Area

The paper develops a deep plasma profiling method to identify biomarker candidates for cancers, finding that low-abundance proteins are critical for accurate classification.

Mechanical and possible auxetic properties of human Achilles tendon during in vitro testing to failure

This study investigates the mechanical properties of human Achilles tendon during in vitro testing to failure, revealing auxetic behavior and strain distribution patterns.

Methylothon: a versatile course-based high school research experience in microbiology and bioinformatics-- with pink bacteria

Methylothon is a high school research module on microbiology and bioinformatics using pink bacteria, offering both in-person and remote versions with bioinformatics tools and community science participation.

Optimization of Non-Coding Regions Improves Protective Efficacy of an mRNA SARS-CoV-2 Vaccine in Nonhuman Primates

This study compares two mRNA SARS-CoV-2 vaccines in nonhuman primates, showing that CV2CoV, with optimized non-coding regions, provides better immune responses and protection than CVnCoV.