Epistasis, aneuploidy, and gain-of-function mutations underlie the evolution ofresistance to induced microtubule depolymerization
M. Pavani, P. Bonaiuti, E. Chiroli, F. Gross, F. Natali, F. Macaluso, A. Poti, S. Pasqualato, S. Pompei, M. Cosentino Lagomarsino, G. Rancati, D. Szuts, A. Ciliberto
The paper evolves yeast populations with impaired microtubule polymerization and identifies mutations and chromosome duplications that confer resistance to microtubule depolymerizing drugs.
bioRxiv · Oct 7, 2020 · PreprintCell Biology