F. Gross

Preclinical development of non-viral gene therapy for patients with advanced pancreatic cancer

This paper develops a non-viral gene therapy, CYL-02, for pancreatic cancer, demonstrating its safety, biodistribution, and therapeutic efficacy when combined with gemcitabine.

Apelin-VEGF-C mRNA delivery as therapeutic for the treatment of secondary lymphedema

This study identifies apelin as a therapeutic molecule for secondary lymphedema, showing it enhances lymphatic function through VEGF-C and pathways involving Akt and eNOS, with a novel RNA delivery system for clinical evaluation.

Epistasis, aneuploidy, and gain-of-function mutations underlie the evolution ofresistance to induced microtubule depolymerization

The paper evolves yeast populations with impaired microtubule polymerization and identifies mutations and chromosome duplications that confer resistance to microtubule depolymerizing drugs.

Effector membrane translocation biosensors reveal G protein and β-arrestin coupling profiles of 100 therapeutically relevant GPCRs

The paper develops EMTA biosensors to profile G protein and β-arrestin coupling of 100 GPCRs, revealing diverse signaling profiles and drug-target interactions.

PP1 and PP2A use opposite phospho-dependencies to control distinct processes at the kinetochore

The paper shows PP1 and PP2A-B56 use opposite phospho-dependencies to control distinct mitotic processes at the kinetochore through differential kinase input responses.