Breadth of Fc-mediated effector function delineates grades of clinical immunity following human malaria challenge
I. N. Nkumama, D. Odera, F. Musasia, K. Mwai, L. Nyamako, L. Murungi, J. Tuju, K. Furle, M. Rosenkranz, R. Kimathi, P. Njuguna, M. Hamaluba, M. C. Kapulu, R. Frank, CHMI-SIKA Study Team, F. Osier
The paper compares seven antibody assays to identify which best correlate with immunity to malaria, finding that Fc-mediated effector function breadth is a strong indicator of protection.
bioRxiv · Oct 11, 2022 · PreprintImmunology