D. Wirth

Utility of FRET in studies of membrane protein oligomerization: the concept of the effective dissociation constant

This paper introduces an effective dissociation constant derived from FRET measurements to quantify membrane receptor oligomerization and activity.

Quantification of ligand and mutation-induced bias in EGFR phosphorylation in direct response to ligand binding

The paper quantifies ligand and mutation-induced bias in EGFR phosphorylation directly after ligand binding, showing that both factors influence RTK signaling without feedback loop contributions.

Plasticity of transmembrane helix interactions in EphA2 dimers and oligomers

The paper investigates how EphA2 transmembrane helix mutations affect receptor-receptor interactions using FRET and FIF, finding plasticity in dimer interfaces rather than a binary switch between active/inactive states.

High-throughput profiling of natural acquired humoral immune response to a large panel of known and novel full length ectodomain P. falciparum merozoite vaccine candidates under reduced malaria transmission.

The paper profiles natural humoral immunity to P. falciparum vaccine candidates in a low transmission setting, identifying antigens that induce high, moderate, or low antibody responses.

Direct quantification of ligand-induced lipid and protein microdomains with distinctive signaling properties

The paper directly observes ligand-induced GM1 and EphA2 microdomains in live cells and shows differential EphA2 signaling in these domains.

Antimalarials in mosquitoes overcome Anopheles and Plasmodium resistance to malaria control strategies

This paper demonstrates that antimalarial drugs can block malaria transmission by targeting mosquitoes, remaining effective against resistant strains of both mosquitoes and parasites.

Tension causes structural unfolding of intracellular intermediate filaments

The paper uses Raman imaging to show that intracellular vimentin unfolds under cellular tension, indicating IFs act as force sensors.