Pharmacology & ToxicologybioRxiv
Comparison of morphine, oxycodone and the biased MOR agonist SR-17018 for tolerance and efficacy in mouse models of pain.
F. Pantouli, T. W. Grim, C. L. Schmid…·L. M. Bohn
This study compares the tolerance and efficacy of morphine, oxycodone, and the biased MOR agonist SR-17018 in mouse pain models, finding SR-17018 retains efficacy in most models despite developing tolerance in some.
DOI 10.1016/j.neuropharm.2020.108439