F. Pierrel

COQ4 is required for the oxidative decarboxylation of the C1 carbon of Coenzyme Q in eukaryotic cells

This study identifies COQ4 as catalyzing the oxidative decarboxylation of the C1 carbon in CoQ biosynthesis in eukaryotic cells.

Role of the Escherichia coli ubiquinone-synthesizing UbiUVT pathway in adaptation to changing respiratory conditions

This paper investigates the role of the UbiUV-dependent ubiquinone biosynthesis pathway in E. coli adaptation to changing oxygen conditions and identifies its importance in anaerobic respiration and uracil biosynthesis.

The prion and HSP104 modulate cytochrome c oxidase deficiency caused by deletion of COX12

The paper shows that deletion of COX12 in yeast leads to cytochrome c oxidase deficiency, which is mitigated by HSP104 and the loss of the [PSI+] prion.

The biosynthetic pathway of ubiquinone contributes to pathogenicity of Francisella

This study identifies the ubiquinone biosynthetic pathway in Francisella novicida, showing UQ8 as the major quinone and demonstrating its essential role in growth and pathogenicity.

The O2-independent pathway of ubiquinone biosynthesis is essential for denitrification in Pseudomonas aeruginosa

Ubiquinone biosynthesis over the entire O2 range: characterization of a conserved, O2-independent pathway

The paper identifies an O2-independent ubiquinone biosynthesis pathway in bacteria, showing its presence in human pathogens and its role in metabolic flexibility across O2 gradients.