J. Thomas

Eicosapentaenoic Acid Enhances Angiogenesis and Reperfusion After Ischemia: Comparative Effects of Omega-3 Fatty Acids in a Murine Hind Limb Model

This study compares the effects of EPA and DHA on angiogenesis and reperfusion in a murine hind limb ischemia model, finding EPA enhances reperfusion and angiogenesis while DHA does not.

SARS-CoV-2 S, M and E Structural Proteins Down-modulate HIV-1 LTR Activity and Modulate Endoplasmic Reticulum Stress Responses

This study shows SARS-CoV-2 S, M, and E proteins reduce HIV-1 LTR activity and modulate ER stress by down-regulating NF-κB, while N protein does not.

Early-stage idiopathic pulmonary fibrosis is characterized by bronchoalveolar accumulation of SPP1+ macrophages

This study identifies SPP1+ macrophages as early-stage biomarkers in idiopathic pulmonary fibrosis using single-cell transcriptomics and flow cytometry.

LKB1 suppresses growth and promotes the internalization of EGFR through the PIKFYVE lipid kinase

This study identifies LKB1's role in suppressing growth by activating PIKFYVE to promote EGFR internalization in LUAD.

Alstrom syndrome proteins regulate centriolar cartwheel assembly by enabling Plk4-Ana2 amplification loop in Drosophila

This study identifies Alms1a and Alms1b as regulators of centriole duplication in Drosophila by enabling the Plk4-Ana2 amplification loop and Sas-6 recruitment.

Lineage-specific intolerance to oncogenic drivers restricts histological transformation

The paper models histological transformation of lung cancer and identifies neuroendocrine-specific tolerance to Myc as an oncogenic driver.

Reinstating targeted protein degradation with DCAF1 PROTACs in CRBN PROTAC resistant settings

This study develops DCAF1-based PROTACs to overcome CRBN resistance in targeted protein degradation, demonstrating effective degradation of BTK in CRBN-resistant cells.

A laser capture microdissection transcriptome of M. truncatula roots responding to rhizobia reveals spatiotemporal tissue expression patterns of genes involved in nodule signaling and organogenesis

The paper presents a transcriptome resource analyzing spatiotemporal gene expression in M. truncatula roots during rhizobial inoculation, revealing tissue-specific expression patterns and identifying genes involved in nodule signaling and organogenesis.

The Ecology of Viruses in Urban Rodents with a Focus on SARS-CoV-2

The study investigates viral ecology in urban rodents during the COVID-19 pandemic, finding no SARS-CoV-2 infection but evidence of potential exposure through antibodies.

A collaborative approach to improving representation in viral genomic surveillance

This paper develops a collaborative genomic surveillance model to improve representation in rural and minority communities, generating over 1,000 SARS-CoV-2 genomes and identifying new variants.

Validity of Optical Heart Rate Measurement in Commercially Available Wearable Fitness Tracking Devices

This study evaluates the accuracy of optical heart rate measurement in three wearable devices under different conditions, finding they meet ANSI/CTA standards for physical activity monitoring.

Quantitative proteomics and lipidomics of TFG-deficient B cells provide insights into mechanisms of autophagic flux and plasma cell biology

This study uses proteomics and lipidomics to analyze TFG-deficient B cells, identifying TFG's role in autophagy, plasma cell biology, and lipid homeostasis.

Designing Cost-Effective, Open-Source, Multi-Head Bioprinters via Conversion of Hobby-Grade 3D Printers

This paper converts hobby-grade 3D printers into low-cost, open-source, multi-head bioprinters for tissue engineering applications.

Invasive slipper limpets Crepidula fornicata act like a sink, rather than source, of Vibrio spp.

The study surveys the health of invasive slipper limpets Crepidula fornicata for Vibrio spp. and finds they harbor high bacterial loads but show no signs of disease or pathogenicity.

The prion and HSP104 modulate cytochrome c oxidase deficiency caused by deletion of COX12

The paper shows that deletion of COX12 in yeast leads to cytochrome c oxidase deficiency, which is mitigated by HSP104 and the loss of the [PSI+] prion.

Low numbers of cytokine transcripts drive inflammatory skin diseases by initiating amplification cascades in localized epidermal clusters

Increased alpha-helicity of a supercharged coiled-coil protein increases siRNA delivery efficiency of protein-lipid hybrid vehicle

CCR2-dependent monocyte-derived cells restrict SARS-CoV-2 infection

This study identifies a CCR2-dependent monocyte-derived cell mechanism that restricts SARS-CoV-2 infection and inflammation in the lungs of mice.

A Drug-free, Self-destruction Strategy to Combat Bacterial Infections by Using the Intrinsically formed Magnetic Nanoparticles in Bacterial Pathogens

This paper demonstrates a drug-free strategy using magnetic nanoparticles formed by bacteria to combat infections, showing significant bacterial reduction with an alternating magnetic field.

O-specific antigen-dependent surface hydrophobicity mediates aggregate assembly type in Pseudomonas aeruginosa

This study shows that O-specific antigen affects surface hydrophobicity, leading to different aggregate types in Pseudomonas aeruginosa under CF-like conditions.

Improved microbial community characterization of 16S rRNA via metagenome hybridization capture enrichment

The paper develops 16S rRNA sequence capture baits to improve microbial community characterization by balancing the advantages of amplicon and shotgun metagenomic methods.

Betulonic acid derivatives inhibiting coronavirus replication in cell culture via the nsp15 endoribonuclease

This study identifies betulonic acid derivatives as inhibitors of coronavirus replication by targeting the nsp15 endoribonuclease, with EC50 of 0.6 M against 229E.

DNA-SIP and repeated isolation corroborate Variovorax as a key organism in maintaining the genetic memory for linuron biodegradation in an agricultural soil

The study confirms Variovorax as the key linuron-degrading bacterium in agricultural soil using DNA-SIP and repeated isolation.

Phenotypic and functional characterisation of first trimester human placental macrophages, Hofbauer cells.

The paper characterizes first trimester human placental macrophages, identifying Hofbauer cells as HLA-DR-FOLR2+ macrophages with microbicidal properties and secreted factors influencing placental angiogenesis.

Heterogenous susceptibility to R-pyocin killing in populations of Pseudomonas aeruginosa sourced from cystic fibrosis lungs

The paper examines R-pyocin susceptibility in Pseudomonas aeruginosa populations from CF lungs, finding heterogeneous responses due to LPS core variations.

Integration of phenomics and transcriptomics data to reveal drivers of inflammatory processes in the skin

The paper integrates phenomics and transcriptomics data from skin samples to identify gene signatures driving inflammatory processes, revealing new factors like CEBPB and PTTG2.

Automation of citation screening in pre-clinical systematic reviews

The paper develops machine learning classifiers to automate citation screening in pre-clinical systematic reviews, achieving high sensitivity and specificity across different domains.

Chlorotoxin Conjugated with Saporin Reduces Viability of ML-1 Thyroid Cancer Cells In Vitro

This study shows that Chlorotoxin-Saporin conjugate reduces viability of ML-1 thyroid cancer cells in a dose-dependent manner.

Dynamics between horizontal gene transfer and acquired antibiotic resistance in S. Heidelberg following in vitro incubation in broiler ceca

This study shows that S. Heidelberg can acquire antibiotic resistance plasmids from broiler ceca microbiota in vitro, highlighting gene transfer dynamics in the gut.

Low Replication Capacity Virus Is Preferentially Transmitted In Mother-To-Child-Transmission But Not In Adult-To-Adult-Transmission Of HIV-1

The paper compares viral replicative capacity in mother-to-child and adult-to-adult HIV-1 transmission, finding lower replicative capacity in MTCT viruses.