Under the shadow: Old-biased genes are subject to weak purifying selection at both the tissue and cell type-specific levels
M. Yıldız, H. Izgi, F. Rahimova, U. B. Altıntas, Z. G. Turan, M. Somel
The paper shows that old-biased genes show weaker purifying selection in multiple tissues and cell types across diverse species, supporting the mutation accumulation theory of aging.
bioRxiv · Sep 21, 2022Evolutionary Biology